Discovery of a biologically active thiostrepton fragment.

نویسندگان

  • K C Nicolaou
  • Mark Zak
  • Shai Rahimipour
  • Anthony A Estrada
  • Sang Hyup Lee
  • Aurora O'Brate
  • Paraskevi Giannakakou
  • M Reza Ghadiri
چکیده

Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 127 43  شماره 

صفحات  -

تاریخ انتشار 2005